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necrotic cell death as a function of subcellular location, including the nucleus, the cytosol, the endoplasmic reticulum, the mitochondria, and the membrane. In quantum mechanics, a singlet state usually refers to a system in which all electrons are paired. The term 'singlet' originally meant a linked set of particles whose net angular momentum is zero, that is, whose overall spin quantum number s = 0 {\displaystyle s=0}. As a result, there is only one spectral line of a singlet state. In contrast, a doublet state contains one unpaired electron and shows splitting of spectral lines into a doublet; and a triplet state has two unpaired electrons and sh Keywords: singlet oxygen, photoablation and photodynamic therapy, subcellular location, near-infrared, localized reactive oxygen species (ROS), chemoptogenetic, photosensitizer, fluorogen. Citation: Liang P, Kolodieznyi D, Creeger Y, Ballou B and Bruchez MP (2020) Subcellular Singlet Oxygen and Cell Death: Location Matters.
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